Molecular View into Preferential Binding of the Factor VII Gla Domain to Phosphatidic Acid.

ABSTRACT: Factor VII (FVII) is a serine protease with a key role in initiating the coagulation cascade. It is part of a family of vitamin K-dependent clotting proteins, which require vitamin K for formation of their specialized membrane-binding domains (Gla domains). Membrane binding of the FVII Gla domain is critical to the activity of FVII, mediating the formation of its complex with other clotting factors. While Gla domains among coagulation factors are highly conserved in terms of amino acid sequence and structure, they demonstrate differential binding specificity toward anionic lipids. Although most Gla domain-containing clotting proteins display a strong preference for phosphatidylserine (PS), it has been demonstrated that FVII and protein C instead bind preferentially to phosphatidic acid (PA

SUBMITTER: Muller MP 

PROVIDER: S-EPMC9637449 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature