The Role of Ferroptosis-Related Molecules and Significance of Ferroptosis Score in Cervical Cancer.

ABSTRACT:

Background

Ferroptosis, a form of cell death driven by iron-dependent lipid peroxidation, may be a potential treatment for many cancers, including cervical cancer (CC). However, the regulation of long noncoding RNAs (lncRNAs) in the process of ferroptosis and whether ferroptosis inducers could increase the cytotoxicity of conventional chemotherapy drugs remain to be further elucidated.

Methods

We analyzed the variation of 55 differentially ferroptosis-related genes (FRGs) and the influence of mutations in CC patients. The patients with CC were classified into two ferroptosis clusters by the non-negative matrix factorization (NMF) algorithm. The principal components analysis (PCA) was used to measure the ferroptosis score (FerroScore) in patients with CC. Besides, FerroScore

SUBMITTER: Li P 

PROVIDER: S-EPMC9637471 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature