Reliability of Ancestry-specific Prostate Cancer Genetic Risk Score in Four Racial and Ethnic Populations.

ABSTRACT:

Background

Reliability of prostate cancer (PCa) genetic risk score (GRS), that is, the concordance between its estimated risk and observed risk, is required for genetic testing at the individual level. Reliability data are lacking for non-European racial/ethnic populations, which hinders its clinical use and exacerbates racial disparity.

Objective

To calibrate PCa ancestry-specific GRS in four racial/ethnic populations.

Design setting and participants

PCa ancestry-specific GRSs, calculated from published risk-associated single-nucleotide polymorphisms in corresponding racial/ethnic populations, were evaluated in men who participated in 23andMe, Inc. genetic testing and consented for research, including 888 086 of European (EUR), 81 109 of Hispanic (HIS), 30 472 of Afr

SUBMITTER: Shi Z 

PROVIDER: S-EPMC9637567 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature