Expression of basement membrane genes and their prognostic significance in clear cell renal cell carcinoma patients.

ABSTRACT:

Background

Clear cell renal cell carcinoma (ccRCC) is a malignant tumor with limited treatment options. A recent study confirmed the involvement of basement membrane (BM) genes in the progression of many cancers. Therefore, we studied the role and prognostic significance of BM genes in ccRCC.

Methods

Co-expression analysis of ccRCC-related information deposited in The Cancer Genome Atlas database and a BM geneset from a recent study was conducted. The differentially expressed BM genes were validated using quantitative reverse-transcription polymerase chain reaction (qRT-PCR). Least absolute shrinkage and selection operator regression and univariate Cox regression analyses were performed to identify a BM gene signature with prognostic significance for ccRCC. Multivariate Cox

SUBMITTER: Tao J 

PROVIDER: S-EPMC9637577 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature