Networks of inflammation, depression, and cognition in aging males and females.

ABSTRACT:

Background

Prioritizing the maintenance of healthy cognitive aging and personalizing preventive interventions to enhance their effectiveness is crucial as the global population ages. Systemic inflammation and depression in older people have been associated with decreased levels of cognition but results have been inconsistent.

Aims

To explore the interactive network of inflammation, depression and cognition by sex in older people.

Methods

We used novel network analysis to explore the unique associations between inflammatory biomarkers, depression, cognition, and somatic, genetic, and lifestyle risk factors in an older (aged 70-90 years), non-demented, community-dwelling sample from the longitudinal Sydney Memory and Aging Study (N = 916) at baseline and at a two-year f

SUBMITTER: Chalmers RA 

PROVIDER: S-EPMC9637618 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature