Dataset Information

Trajectories of MMSE and MoCA scores across the healthy adult lifespan in the Italian population.

ABSTRACT:

Background

This study compares the performance at the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) across the healthy adult lifespan in an Italian population sample.

Methods

The MMSE and MoCA were administered to 407 Italian healthy native-speakers (165 males; age range 20-93 years; education range 4-25 years). A generalized Negative Binomial mixed model was run to profile MMSE and MoCA scores across 8 different age classes (≤ 30; 31-40; 41-50; 51-60; 61-70; 71-80; 81-85; ≥ 86) net of education and sex.

Results

MMSE and MoCA total scores declined with age (p < 0.001), with the MoCA proving to be "more difficult" than the MMSE (p < 0.001). The Age*Test interaction (p < 0.001) indicates that the MoCA proved to profile a sufficiently linear involutional trend in cognition with advancing age and to be able to detect poorer cognitive performances in individuals aged ≥ 71 years. By contrast, MMSE scores failed in capturing the expected age-related trajectory, reaching a plateau in the aforementioned age classes.

Discussion

The MoCA seems to be more sensitive than the MMSE in detecting age-related physiological decline of cognitive functioning across the healthy adult lifespan. The MoCA might be therefore more useful than the MMSE as a test for general cognitive screening aims.

SUBMITTER: Aiello EN

PROVIDER: S-EPMC9637628 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Trajectories of MMSE and MoCA scores across the healthy adult lifespan in the Italian population.

Aiello Edoardo Nicolò EN Pasotti Fabrizio F Appollonio Ildebrando I Bolognini Nadia N

Aging clinical and experimental research 20220702 10

<h4>Background</h4>This study compares the performance at the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) across the healthy adult lifespan in an Italian population sample.<h4>Methods</h4>The MMSE and MoCA were administered to 407 Italian healthy native-speakers (165 males; age range 20-93 years; education range 4-25 years). A generalized Negative Binomial mixed model was run to profile MMSE and MoCA scores across 8 different age classes (≤ 30; 31-40; 41-50; 51- ...[more]

PMID: 35780219

Similar Datasets

Project description:BackgroundTraumatic Brain Injury (TBI) is the most common cause of injury-related death and disability globally, and a common sequelae is cognitive impairment. Addressing post-TBI cognitive deficits is crucial because they affect rehabilitation outcomes, but doing this requires valid and reliable cognitive assessment measures. However, no such instrument has been validated in Tanzania's TBI population. Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) are two commonly used instruments to measure cognitive impairment, and there have been a few studies reporting their use in post-TBI cognitive assessment. Our aim was to report the psychometric properties of the Swahili version of both scales amongst the TBI population in Tanzania.MethodsA cross-cultural adaptation committee participated in the translation and content validation process for both questionnaires. Our patient sample consisted of 192 adults with TBI who were admitted to Kilimanjaro Christian Medical Center (KCMC) in Tanzania. Confirmatory factor analysis, reliability and external validity were evaluated.ResultsMoCA showed adequate factor loadings (values > 0.50 for all items except items 7 & 10) and adequate reliability (values > 0.70). Factor loadings for most of the MMSE items were below 0.5 and internal consistency was medium (< 0.7). Polychoric correlation between MMSE and MoCA was strong, positive and statistically significant (r = 0.68, p = 0.001); correlation with the cognitive subscale of FIM indicated moderately positive relationships - MMSE (r = 0.35, p = 0.001) and MoCA (r = 0.43, p = 0.001).ConclusionsWith the exception of the language and memory items, MoCA is a valid and reliable instrument for cognitive impairment screening in Tanzania's adult TBI population. On the other hand, MMSE does not appear to be an appropriate tool in this patient group, but its positive correlations with MoCA and cFIM indicate similar theoretical concepts. Both instruments require further validation studies to prove their predictive ability for screening cognitive impairment before they are considered suitable for clinical use.

Dataset Information

Trajectories of MMSE and MoCA scores across the healthy adult lifespan in the Italian population.

Background

Methods

Results

Discussion

Publications

Trajectories of MMSE and MoCA scores across the healthy adult lifespan in the Italian population.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets