Comprehensive profiling of the human viral exposome in households containing an at-risk child with mitochondrial disease during the 2020-2021 COVID-19 pandemic.

ABSTRACT:

Background

Viral infection is a major cause of morbidity in children with mitochondrial disease (MtD). As a result, families with children with MtD are highly adherent to risk mitigation behaviours (RMBs) advised by the Centers for Disease Control and Prevention during the COVID-19 pandemic that can modulate infection risk.

Methods

Deep serologic phenotyping of viral infections was performed via home-based sampling by combining SARS-CoV-2 serologic testing and phage display immunoprecipitation and sequencing. Samples were collected approximately 1 year apart (October 2020 to April 2021 and October 2021 to March 2022) on households containing a child with MtD.

Results

In contrast to our first collection in 2020-2021, SARS-CoV-2 antibody profiles for all participants in

SUBMITTER: Gordon-Lipkin EM 

PROVIDER: S-EPMC9637669 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature