Genome-wide screening of sex-biased genetic variants potentially associated with COVID-19 hospitalization.

ABSTRACT: Sex-biased difference in coronavirus disease 2019 (COVID-19) hospitalization has been observed as that male patients tend to be more likely to be hospitalized than female patients. However, due to the insufficient sample size and existed studies that more prioritized to sex-stratified COVID-19 genome-wide association study (GWAS), the searching for sex-biased genetic variants showing differential association signals between sexes with COVID-19 hospitalization was severely hindered. We hypothesized genetic variants would show potentially sex-biased genetic effects on COVID-19 hospitalization if they display significant differential association effect sizes between male and female COVID-19 patients. By integrating two COVID-19 GWASs, including hospitalized COVID-19 patients vs. general popul

SUBMITTER: Luo YS 

PROVIDER: S-EPMC9637711 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature