Conversion of ER, PR, HER2 and Ki-67 and Prognosis in breast cancer metastases to the brain.

ABSTRACT:

Objective

This study aimed to analyze the expression levels of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER-2), and Ki-67 proliferation index in the brain metastatic lesions and primary lesions in Chinese patients with breast cancer brain metastasis (BCBM) and determine the correlation between their changes and patients' survival.

Methods

A retrospective analysis was performed on patients with BCBM. The clinical characteristic of these patients was collected. The differences in the expression levels of the ER, PR, HER-2, and Ki-67 index between the primary lesions and brain lesions were evaluated, and the association between the differences and survival was analyzed.

Results

The conversion rate of anyone receptor (E

SUBMITTER: Jiaxin C 

PROVIDER: S-EPMC9637832 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature