Liver injury during durvalumab-based immunotherapy is associated with poorer patient survival: A retrospective analysis.

ABSTRACT:

Background

Durvalumab is approved for the treatment of lung cancer, advanced biliary tract cancers, and is also being evaluated in many other solid organ tumors. The aim of our study is to define the incidence, etiology, and outcomes of liver injury in consecutive patients receiving durvalumab-based immunotherapy.

Patients and methods

Durvalumab treated patients between 1/2016 - 7/2020 were identified from the electronic medical record. Liver injury was defined as serum AST or ALT ≥ 5x upper limit of normal (ULN), ALP ≥ 2x ULN, bilirubin ≥ 2.5 mg/dl, or INR ≥ 1.5. Potential drug induced liver injury (DILI) cases were adjudicated using expert opinion scoring and confirmed with Roussel Uclaf Causality Assessment Method (RUCAM).

Results

Amongst 112 patients, 58 (52%) had

SUBMITTER: Swanson LA 

PROVIDER: S-EPMC9637844 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature