TM6SF2 rs58542926 is related to hepatic steatosis, fibrosis and serum lipids both in adults and children: A meta-analysis.

ABSTRACT:

Background and aims

Findings about the associations between transmembrane 6 superfamily member 2 (TM6SF2) rs58542926 and nonalcoholic fatty liver disease have not been consistently replicated, particularly in steatosis and fibrosis. The present study aimed to investigate the associations between the rs58542926T allele and the spectrum of NAFLD and its related metabolic phenotypes.

Methods

Systematic literature research was performed to analyse the associations between rs58542926 and the spectrum of NAFLD and its related metabolic phenotypes. A random effects meta-analysis with a dominant genetic model was applied.

Results

Data from 123,800 individuals across 44 studies were included in the current meta-analysis.rs58542926 T allele was associated with an increas

SUBMITTER: Li XY 

PROVIDER: S-EPMC9637980 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature