Transcriptome and morphological analysis on the heart in gestational protein-restricted aging male rat offspring.

ABSTRACT: Background: Adverse factors that influence embryo/fetal development are correlated with increased risk of cardiovascular disease (CVD), type-2 diabetes, arterial hypertension, obesity, insulin resistance, impaired kidney development, psychiatric disorders, and enhanced susceptibility to oxidative stress and inflammatory processes in adulthood. Human and experimental studies have demonstrated a reciprocal relationship between birthweight and cardiovascular diseases, implying intrauterine adverse events in the onset of these abnormalities. In this way, it is plausible that confirmed functional and morphological heart changes caused by gestational protein restriction could be related to epigenetic effects anticipating cardiovascular disorders and reducing the survival time of these ani

SUBMITTER: Folguieri MS 

PROVIDER: S-EPMC9638007 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature