(1S,3R)-N-{(3S,10S,12S,13R,17R)-12-Hy-droxy-17-[(R)-5-hy-droxy-pentan-2-yl]-10,13-di-methyl-hexa-deca-hydro-1H-cyclo-penta-[a]phenanthren-3-yl}adamantane-1-carboxamide 0.25-hydrate.

ABSTRACT: The title compound, C₃₅H₅₇NO₃·0.25H₂O, was synthesized from de-oxy-cholic acid followed by a protection, a Mitsonobu substitution, a Staudinger reduction, formation of an amide and final reduction in the lateral chain. The compound crystallizes in the P1 space group with four steroid mol-ecules and one water mol-ecule in the triclinic cell unit. The crystal structure features O-H⋯O hydrogen bonding. The crystal studied was refined as a non-merohedral twin.

SUBMITTER: Campos Fernandez C 

PROVIDER: S-EPMC9638062 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature