High-resolution spatiotemporal analysis of single serotonergic axons in an in vitro system.

ABSTRACT: Vertebrate brains have a dual structure, composed of (i) axons that can be well-captured with graph-theoretical methods and (ii) axons that form a dense matrix in which neurons with precise connections operate. A core part of this matrix is formed by axons (fibers) that store and release 5-hydroxytryptamine (5-HT, serotonin), an ancient neurotransmitter that supports neuroplasticity and has profound implications for mental health. The self-organization of the serotonergic matrix is not well understood, despite recent advances in experimental and theoretical approaches. In particular, individual serotonergic axons produce highly stochastic trajectories, fundamental to the construction of regional fiber densities, but further advances in predictive computer simulations require

SUBMITTER: Hingorani M 

PROVIDER: S-EPMC9638127 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature