MicroRNAs in Kawasaki disease: An update on diagnosis, therapy and monitoring.

ABSTRACT: Kawasaki disease (KD) is an acute autoimmune vascular disease featured with a long stage of febrile. It predominantly afflicts children under 5 years old and causes an increased risk of cardiovascular combinations. The onset and progression of KD are impacted by many aspects, including genetic susceptibility, infection, and immunity. In recent years, many studies revealed that miRNAs, a novel class of small non-coding RNAs, may play an indispensable role in the development of KD via differential expression and participation in the central pathogenesis of KD comprise of the modulation of immunity, inflammatory response and vascular dysregulation. Although specific diagnose criteria remains unclear up to date, accumulating clinical evidence indicated that miRNAs, as small molecules, c

SUBMITTER: Xiong Y 

PROVIDER: S-EPMC9638168 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature