The Neuroepigenetic Landscape of Vertebrate and Invertebrate Models of Neurodegenerative Diseases.

ABSTRACT: Vertebrate and invertebrate models of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, have been paramount to our understanding of the pathophysiology of these conditions; however, the brain epigenetic landscape is less well established in these disease models. DNA methylation, histone modifications, and microRNAs are among commonly studied mechanisms of epigenetic regulation. Genome-wide studies and candidate studies of specific methylation marks, histone marks, and microRNAs have demonstrated the dysregulation of these mechanisms in models of neurodegenerative diseases; however, the studies to date are scarce and inconclusive and the implications of many of these changes are still not fully understood. In this review, we sum

SUBMITTER: Sundaramoorthy TH 

PROVIDER: S-EPMC9638687 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature