IGF1R is a mediator of sex-specific metabolism in mice: Effects of age and high-fat diet.

ABSTRACT:

Objective

We aimed to investigate the short and long-term metabolic consequences of IGF1R systemic gene deficiency in mice.

Methods

UBC-CreERT2, Igf1r^fl/fl mutant mice were used to suppress IGF1R signaling in adult tissues by inducing postnatal generalized Igf1r deletion with tamoxifen. Animals were analyzed at two different ages: i) 13-weeks old young mice, and ii) 12-months old middle-aged mice. In addition, the effects of 10 weeks-long high-fat diet (HFD) were investigated in middle-aged mice.

Results

Young IGF1R-deficient mice were insulin-resistant, with high IGF1, growth hormone (GH) and IGFBP3, as well as low IGFBP2 circulating levels. Males also presented increased triglycerides in liver. In contrast, middle-aged mice did

SUBMITTER: Perez-Matute P 

PROVIDER: S-EPMC9638844 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature