Design and Synthesis of Visible-Light-Responsive Azobenzene Building Blocks for Chemical Biology.

ABSTRACT: Tetra-ortho-fluoro-azobenzenes are a class of photoswitches useful for the construction of visible-light-controlled molecular systems. They can be used to achieve spatio-temporal control over the properties of a chosen bioactive molecule. However, the introduction of different substituents to the tetra-fluoro-azobenzene core can significantly affect the photochemical properties of the switch and compromise biocompatibility. Herein, we explored the effect of useful substituents, such as functionalization points, attachment handles, and water-solubilizing groups, on the photochemical properties of this photochromic system. In general, all the tested fluorinated azobenzenes exhibited favorable photochemical properties, such as high photostationary state distribution and long half-lives

SUBMITTER: Volaric J 

PROVIDER: S-EPMC9639001 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature