Comparative efficacy and complications of long-acting and intermediate-acting insulin regimens for adults with type 1 diabetes: an individual patient data network meta-analysis.

ABSTRACT:

Objective

To examine the comparative efficacy and complications of long-acting and intermediate-acting insulin for different patient characteristics for type 1 diabetes mellitus (T1DM).

Design

Systematic review and individual patient data (IPD) network meta-analysis (NMA).

Data sources

MEDLINE, EMBASE and the Cochrane Central Register of Controlled Trials were searched through June 2015.

Eligibility criteria

Randomised controlled trials (RCTs) on adults with T1DM assessing glycosylated haemoglobin (A1c) and severe hypoglycaemia in long-acting and intermediate-acting insulin regimens.

Data extraction and synthesis

We requested IPD from authors and funders. When IPD were not available, we used aggregate data. We conducted a random-effects model, and specif

SUBMITTER: Veroniki AA 

PROVIDER: S-EPMC9639076 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature