Speech silence character as a diagnostic biomarker of early cognitive decline and its functional mechanism: a multicenter cross-sectional cohort study.

ABSTRACT:

Background

Language deficits frequently occur during the prodromal stages of Alzheimer's disease (AD). However, the characteristics of linguistic impairment and its underlying mechanism(s) remain to be explored for the early diagnosis of AD.

Methods

The percentage of silence duration (PSD) of 324 subjects was analyzed, including patients with AD, amnestic mild cognitive impairment (aMCI), and normal controls (NC) recruited from the China multi-center cohort, and the diagnostic efficiency was replicated from the Pitt center cohort. Furthermore, the specific language network involved in the fragmented speech was analyzed using task-based functional magnetic resonance.

Results

In the China cohort, PSD increased significantly in aMCI and AD patients. The area under the cu

SUBMITTER: Wang HL 

PROVIDER: S-EPMC9639269 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature