Population-based analysis of radiation-induced gliomas after cranial radiotherapy for childhood cancers

ABSTRACT: Abstract

Background

Cranial radiotherapy (RT) used for pediatric CNS cancers and leukemias carries a risk of secondary CNS malignancies, including radiation-induced gliomas (RIG). Our aim was to characterize the epidemiology of RIG.

Methods

This retrospective study used SEER data (1975–2016). Cohort 1 included patients diagnosed with glioma as a second malignancy ≥2 years after receiving treatment for a first malignancy diagnosed at 0–19 years, either a primary CNS tumor (1a, n = 57) or leukemia (1b, n = 20). Cohort 2 included patients who received RT for a pediatric CNS tumor and died of presumed progressive disease >7 years after diagnosis, since previous studies have documented many missed RIGs in this group (n = 296). Controls (n = 10 687) included all other patients

SUBMITTER:  

PROVIDER: S-EPMC9639354 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature