Patterning Microtubule Network Organization Reshapes Cell-Like Compartments.

ABSTRACT: Eukaryotic cells contain a cytoskeletal network comprised of dynamic microtubule filaments whose spatial organization is highly plastic. Specialized microtubule architectures are optimized for different cell types and remodel with the oscillatory cell cycle. These spatially distinct microtubule networks are thought to arise from the activity and localization of microtubule regulators and motors and are further shaped by physical forces from the cell boundary. Given complexities and redundancies of a living cell, it is challenging to disentangle the separate biochemical and physical contributions to microtubule network organization. Therefore, we sought to develop a minimal cell-like system to manipulate and spatially pattern the organization of cytoskeletal components in real-time, providi

SUBMITTER: Bermudez JG 

PROVIDER: S-EPMC9639379 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature