Single-cell transcriptomics of human gut T cells identifies cytotoxic CD4⁺CD8A⁺ T cells related to mouse CD4 cytotoxic T cells.

ABSTRACT: Cytotoxic CD4⁺ T cells (CD4-CTLs) show the presence of cytolytic granules, which include the enzymes granzyme and perforin. The cells have a pathogenic and protective role in various diseases, including cancer, viral infection, and autoimmune disease. In mice, cytotoxic CD4⁺ T cells express CD8αα⁺ and reside in the intestine (mouse CD4⁺CTLs; mCD4-CTLs). The population of cytotoxic CD4⁺ T cells in the human intestine is currently unknown. Moreover, it is unclear how cytotoxic CD4 T cells change in patients with inflammatory bowel disease (IBD). Here, we aimed to identify cytotoxic CD4⁺ T cells in the human intestine and analyze the characteristics of the population in patients with IBD using single-cell RNA-seq (scRNA-seq). I

SUBMITTER: Tanemoto S 

PROVIDER: S-EPMC9639511 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature