Age- and disease-specific reference values for neurofilament light presented in an online interactive support interface.
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ABSTRACT:
SUBMITTER: Vermunt L
PROVIDER: S-EPMC9639622 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Publications
Age- and disease-specific reference values for neurofilament light presented in an online interactive support interface.
Vermunt Lisa L Otte Marco M Verberk Inge M W IMW Killestein Joep J Lemstra Afina W AW van der Flier Wiesje M WM Pijnenburg Yolande A L YAL Vijverberg Everard G B EGB Bouwman Femke H FH Gravesteijn Gido G van de Berg Wilma D J WDJ Scheltens Philip P van Harten Argonde C AC Willemse Eline A J EAJ Teunissen Charlotte E CE
Annals of clinical and translational neurology 20221005 11
Interpretation of axonal damage biomarker Neurofilament Light chain (NfL) concentrations is difficult due to the lack of age-specific and disease-specific reference values. We here developed an interactive interface to support interpretation of NfL results in human body fluids. We used NfL values of 1698 individuals without a neurological disorder, aged 19-85 years, and patients with MS and dementias. Percentile regression estimates per diagnosis populate interactive graphs, alongside NfL backgr ...[more]
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