Dataset Information

Cognitive dysfunction 1 year after COVID-19: evidence from eye tracking.

ABSTRACT: Increasing evidence suggests persistent cognitive dysfunction after COVID-19. In this cross-sectional study, frontal lobe function was assessed 12 months after the acute phase of the disease, using tailored eye tracking assessments. Individuals who recovered from COVID-19 made significantly more errors in all eye tracking tasks compared to age/sex-matched healthy controls. Furthermore, patients who were treated as inpatients performed worse compared to outpatients and controls. Our results show impaired inhibitory cortical control in individuals who recovered from COVID-19. The association between disease severity and its sequelae may contribute to a better understanding of post-COVID-19 cognitive function.

SUBMITTER: Carbone F

PROVIDER: S-EPMC9639623 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Cognitive dysfunction 1 year after COVID-19: evidence from eye tracking.

Carbone Federico F Zamarian Laura L Rass Verena V Bair Stefanie S Ritter Marcel M Beer Ronny R Mahlknecht Philipp P Heim Beatrice B Limmert Victoria V Peball Marina M Ellmerer Philipp P Schiefecker Alois Josef AJ Kofler Mario M Lindner Anna A Pfausler Bettina B Putnina Lauma L Kindl Philipp P Löffler-Ragg Judith J Kiechl Stefan S Seppi Klaus K Djamshidian Atbin A Helbok Raimund R

Annals of clinical and translational neurology 20221020 11

Increasing evidence suggests persistent cognitive dysfunction after COVID-19. In this cross-sectional study, frontal lobe function was assessed 12 months after the acute phase of the disease, using tailored eye tracking assessments. Individuals who recovered from COVID-19 made significantly more errors in all eye tracking tasks compared to age/sex-matched healthy controls. Furthermore, patients who were treated as inpatients performed worse compared to outpatients and controls. Our results show ...[more]

PMID: 36264758

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Project description:BackgroundThere is a limited understanding of the cognitive and psychiatric sequelae of COVID-19 during the post-acute phase, particularly among racially and ethnically diverse patients.ObjectiveWe sought to prospectively characterize cognition, mental health symptoms, and functioning approximately four months after an initial diagnosis of COVID-19 in a racially and ethnically diverse group of patients.MethodsApproximately four months after COVID-19 diagnosis, patients in the Johns Hopkins Post-Acute COVID-19 Team Pulmonary Clinic underwent a clinical telephone-based assessment of cognition, depression, anxiety, trauma, and function.ResultsMost Johns Hopkins Post-Acute COVID-19 Team patients assessed were women (59%) and members of racial/ethnic minority groups (65%). Of 82 patients, 67% demonstrated ≥1 abnormally low cognitive score. Patients requiring intensive care unit (ICU) stays displayed greater breadth and severity of impairment than those requiring less intensive treatment. Processing speed (35%), verbal fluency (26%-32%), learning (27%), and memory (27%) were most commonly impaired. Among all patients, 35% had moderate symptoms of depression (23%), anxiety (15%), or functional decline (15%); 25% of ICU patients reported trauma-related distress. Neuropsychiatric symptoms and functional decline did not differ by post-ICU versus non-ICU status and were unrelated to global cognitive composite scores.ConclusionsAt approximately 4 months after acute illness, cognitive dysfunction, emotional distress, and functional decline were common among a diverse clinical sample of COVID-19 survivors varying in acute illness severity. Patients requiring ICU stays demonstrated greater breadth and severity of cognitive impairment than those requiring less intensive treatment. Findings help extend our understanding of the nature, severity, and potential duration of neuropsychiatric morbidity after COVID-19 and point to the need for longitudinal assessment of cognitive and mental health outcomes among COVID-19 survivors of different demographic backgrounds and illness characteristics.

Dataset Information

Cognitive dysfunction 1 year after COVID-19: evidence from eye tracking.

Publications

Cognitive dysfunction 1 year after COVID-19: evidence from eye tracking.

Similar Datasets

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