Association between air pollution and CSF sTREM2 in cognitively normal older adults: The CABLE study.

ABSTRACT:

Objectives

Ambient air pollution aggravates the process of Alzheimer's disease (AD) pathology. Currently, the exact inflammatory mechanisms underlying these links from clinical research remain largely unclear.

Methods

This study included 1,131 cognitively intact individuals from the Chinese Alzheimer's Biomarker and LifestylE database with data provided on cerebrospinal fluid (CSF) AD biomarkers (amyloid beta-peptide 42 [Aβ42], total tau [t-tau], and phosphorylated tau [p-tau]), neuroinflammatory (CSF sTREM2), and systemic inflammatory markers (high sensitivity C-reactive protein and peripheral immune cells). The 2-year averaged levels of ambient fine particulate matter with diameter <2.5 μm (PM_2.5 ), nitrogen dioxide (NO₂ ), and ozone (O₃ )

SUBMITTER: Li M 

PROVIDER: S-EPMC9639632 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature