MicroRNA signatures in genetic frontotemporal dementia and amyotrophic lateral sclerosis.

ABSTRACT:

Objective

MicroRNAs are promising biomarkers of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), but discrepant results between studies have so far hampered their use in clinical trials. We aim to assess all previously identified circulating microRNA signatures as potential biomarkers of genetic FTD and/or ALS, using homogeneous, independent validation cohorts of C9orf72 and GRN mutation carriers.

Methods

104 individuals carrying a C9orf72 or a GRN mutation, along with 31 controls, were recruited through the French research network on FTD/ALS. All subjects underwent blood sampling, from which circulating microRNAs were extracted. We measured differences in the expression levels of 65 microRNAs, selected from 15 published studies about FTD or ALS, betwee

SUBMITTER: Kmetzsch V 

PROVIDER: S-EPMC9639633 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature