Multi-institutional analysis of treatment modalities in basal ganglia and thalamic germinoma.

ABSTRACT:

Background

Central nervous system (CNS) germinomas are treatment-sensitive tumors with excellent survival outcomes. Current treatment strategies combine chemotherapy with radiotherapy (RT) in order to reduce the field and dose of RT. Germinomas originating in the basal ganglia/thalamus (BGTGs) have proven challenging to treat given their rarity and poorly defined imaging characteristics. Craniospinal (CSI), whole brain (WBI), whole ventricle (WVI), and focal RT have all been utilized; however, the best treatment strategy remains unclear.

Methods

Retrospective multi-institutional analysis has been conducted across 18 institutions in four countries.

Results

For 43 cases of nonmetastatic BGTGs, the 5- and 10-year event-free survivals (EFS) were 85.8% and 81.0%, respectiv

SUBMITTER: Graham RT 

PROVIDER: S-EPMC9639702 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature