Blood pressure and the kidney cortex transcriptome response to high-sodium diet challenge in female nonhuman primates.

ABSTRACT: Blood pressure (BP) is influenced by genetic variation and sodium intake with sex-specific differences; however, studies to identify renal molecular mechanisms underlying the influence of sodium intake on BP in nonhuman primates (NHP) have focused on males. To address the gap in our understanding of molecular mechanisms regulating BP in female primates, we studied sodium-naïve female baboons (n = 7) fed a high-sodium (HS) diet for 6 wk. We hypothesized that in female baboons variation in renal transcriptional networks correlates with variation in BP response to a high-sodium diet. BP was continuously measured for 64-h periods throughout the study by implantable telemetry devices. Sodium intake, blood samples for clinical chemistries, and ultrasound-guided kidney biopsies were collec

SUBMITTER: Riojas AM 

PROVIDER: S-EPMC9639778 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature