Transcriptomic analysis supports a role for the nervous system in regulating growth and development of Fasciola hepatica juveniles.

ABSTRACT: Fasciola spp. liver flukes have significant impacts in veterinary and human medicine. The absence of a vaccine and increasing anthelmintic resistance threaten sustainable control and underscore the need for novel flukicides. Functional genomic approaches underpinned by in vitro culture of juvenile Fasciola hepatica facilitate control target validation in the most pathogenic life stage. Comparative transcriptomics of in vitro and in vivo maintained 21 day old F. hepatica finds that 86% of genes are expressed at similar levels across maintenance treatments suggesting commonality in core biological functioning within these juveniles. Phenotypic comparisons revealed higher cell proliferation and growth rates in the in vivo juveniles compared to their in vitro counterparts. These phenotypic dif

SUBMITTER: Robb E 

PROVIDER: S-EPMC9639813 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature