In-silico evaluation of adenoviral COVID-19 vaccination protocols: Assessment of immunological memory up to 6 months after the third dose.

ABSTRACT:

Background

The immune response to adenoviral COVID-19 vaccines is affected by the interval between doses. The optimal interval is unknown.

Aim

We aim to explore in-silico the effect of the interval between vaccine administrations on immunogenicity and to analyze the contribution of pre-existing levels of antibodies, plasma cells, and memory B and T lymphocytes.

Methods

We used a stochastic agent-based immune simulation platform to simulate two-dose and three-dose vaccination protocols with an adenoviral vaccine. We identified the model's parameters fitting anti-Spike antibody levels from individuals immunized with the COVID-19 vaccine AstraZeneca (ChAdOx1-S, Vaxzevria). We used several statistical methods, such as principal component analysis and binary classification

SUBMITTER: Stolfi P 

PROVIDER: S-EPMC9639861 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature