Na_V1.1 is essential for proprioceptive signaling and motor behaviors.

ABSTRACT: The voltage-gated sodium channel (Na_V), Na_V1.1, is well-studied in the central nervous system; conversely, its contribution to peripheral sensory neuron function is more enigmatic. Here, we identify a new role for Na_V1.1 in mammalian proprioception. RNAscope analysis and in vitro patch-clamp recordings in genetically identified mouse proprioceptors show ubiquitous channel expression and significant contributions to intrinsic excitability. Notably, genetic deletion of Na_V1.1 in sensory neurons caused profound and visible motor coordination deficits in conditional knockout mice of both sexes, similar to conditional Piezo2-knockout animals, suggesting that this channel is a major contributor to sensory proprioceptive transmission. Ex vivo muscle aff

SUBMITTER: Espino CM 

PROVIDER: S-EPMC9640190 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature