Targeted Suppression of miRNA-33 Using pHLIP Improves Atherosclerosis Regression.

ABSTRACT:

Background

miRNA therapeutics have gained attention during the past decade. These oligonucleotide treatments can modulate the expression of miRNAs in vivo and could be used to correct the imbalance of gene expression found in human diseases such as obesity, metabolic syndrome, and atherosclerosis. The in vivo efficacy of current anti-miRNA technologies hindered by physiological and cellular barriers to delivery into targeted cells and the nature of miRNAs that allows one to target an entire pathway that may lead to deleterious off-target effects. For these reasons, novel targeted delivery systems to inhibit miRNAs in specific tissues will be important for developing effective therapeutic strategies for numerous diseases including atherosclerosis.

Methods

We used pH low-inser

SUBMITTER: Zhang X 

PROVIDER: S-EPMC9640270 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature