Stereotactic ablative radiation for pancreatic cancer on a 1.5 Telsa magnetic resonance-linac system.

ABSTRACT:

Purpose

Ablative radiation therapy (A-RT) appears to improve outcomes in locally advanced pancreatic cancer (LAPC) yet requires solutions for respiratory and digestive motion. We report outcomes of A-RT for pancreatic cancer using 1.5 T MR-adaptive treatment delivery.

Methods

Between March 2020 and July 2021, we treated 30 patients with pancreatic cancer with 50 Gy in 5 fractions (biologically effective dose [BED10] = 100 Gy10) using a novel compression belt workflow and remote planning on the Unity 1.5 T MR linac system. Cumulative incidence of progression was computed from A-RT initiation with death as a competing risk. Overall (OS) and progression-free survival (PFS) were calculated using Kaplan Meier methods.

Results

Of 30 patients, most (73 %) were locally advanc

SUBMITTER: Tringale KR 

PROVIDER: S-EPMC9640311 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature