Interactions between folate intake and genetic predictors of gene expression levels associated with colorectal cancer risk.

ABSTRACT: Observational studies have shown higher folate consumption to be associated with lower risk of colorectal cancer (CRC). Understanding whether and how genetic risk factors interact with folate could further elucidate the underlying mechanism. Aggregating functionally relevant genetic variants in set-based variant testing has higher power to detect gene-environment (G × E) interactions and may provide information on the underlying biological pathway. We investigated interactions between folate consumption and predicted gene expression on colorectal cancer risk across the genome. We used variant weights from the PrediXcan models of colon tissue-specific gene expression as a priori variant information for a set-based G × E approach. We harmonized total folate intake (mcg/day) based on dietary

SUBMITTER: Haas CB 

PROVIDER: S-EPMC9640550 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature