Predicting vaccine effectiveness against invasive pneumococcal disease in children using immunogenicity data.

ABSTRACT: The strength of the immune response, as measured by antibody concentrations, varies between pneumococcal conjugate vaccines (PCVs). Linking immunogenicity and effectiveness is necessary to assess whether changes in immune response from currently recommended PCVs to next-generation vaccines could impact effectiveness. Simulated reverse cumulative distribution curves were generated using published serotype-specific IgG concentrations with placebo or PCV7. This was combined with the published estimates of serotype-specific vaccine effectiveness of PCV7 against invasive pneumococcal disease to estimate the protective antibody concentration for each serotype in PCV7. Then, based on the published serotype-specific IgG concentrations in PCV13 recipients, reverse cumulative distribution curves wer

SUBMITTER: Ryman J 

PROVIDER: S-EPMC9640717 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature