Genetic and immune changes in Tibetan high-altitude populations contribute to biological adaptation to hypoxia.

ABSTRACT:

Background

Tibetans have lived at very high altitudes for thousands of years, and have a distinctive suite of physiological traits that enable them to tolerate environmental hypoxia. Expanding awareness and knowledge of the differences in hematology, hypoxia-associated genes, immune system of people living at different altitudes and from different ethnic groups may provide evidence for the prevention of mountain sickness.

Method

Ninety-five Han people at mid-altitude, ninety-five Tibetan people at high-altitude and ninety-eight Han people at high-altitude were recruited. Red blood cell parameters, immune cells, the contents of cytokines, hypoxia-associated gene single nucleotide polymorphisms (SNPs) were measured.

Results

The values of Hematocrit (HCT), Mean cell volu

SUBMITTER: Bai J 

PROVIDER: S-EPMC9640738 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature