Negative results of bronchoalveolar lavage fluid metagenomic next-generation sequencing in critically ill patients.

ABSTRACT:

Objective

Reports on negative results of metagenomic next-generation sequencing (mNGS) are scarce. We aimed to explore the diagnostic value of negative results in bronchoalveolar lavage fluid (BALF) mNGS and how to deal with the negative results in patients with severe respiratory disease.

Methods

A retrospective analysis was performed on patients suspected severe community-acquired pneumonia who were admitted to the respiratory intensive care unit of the First Affiliated Hospital of Zhengzhou University from January 2020 to December 2021. According to the final diagnosis as the reference standard, the negative results of mNGS were divided into a true negative group and a false negative group. For enrolled patients, we recorded their demographic data, imaging results, labora

SUBMITTER: Ma W 

PROVIDER: S-EPMC9640831 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature