Pharmacogenes that demonstrate high association evidence according to CPIC, DPWG, and PharmGKB.

ABSTRACT:

Background

Different levels of evidence related to the variable responses of individuals to drug treatment have been reported in various pharmacogenomic (PGx) databases. Identification of gene-drug pairs with strong association evidence can be helpful in prioritizing the implementation of PGx guidelines and focusing on a gene panel. This study aimed to determine the pharmacogenes with the highest evidence-based association and to indicate their involvement in drug-gene interactions.

Methodology

The publicly available datasets CPIC, DPWG, and PharmGKB were selected to determine the pharmacogenes with the highest drug outcome associations. The upper two levels of evidence rated by the three scoring methods were specified (levels A-B in CPIC, 3-4 in DPWG, or 1-2 levels in Pharm

SUBMITTER: Alshabeeb MA 

PROVIDER: S-EPMC9640910 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature