Causal risk factors for asthma in Mendelian randomization studies: A systematic review and meta-analysis.

ABSTRACT:

Background

Several risk factors for asthma have been proposed; however, the causality of these associations is sometimes unclear. Mendelian randomization is a powerful epidemiological approach that can help elucidate the causality of risk factors. The aim of the present study was to identify causal risk factors for asthma through Mendelian Randomization studies.

Methods

A systematic search of PubMed and EMBASE was conducted, to identify studies investigating risk factors for asthma or respiratory allergies through Mendelian Randomization. When two or more studies investigated the same risk factor a meta-analysis was conducted. Of 239 studies initially identified, 41 were included.

Results

A causal association between adiposity and adult asthma risk was found in 10 out

SUBMITTER: Mikkelsen H 

PROVIDER: S-EPMC9640961 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature