Nrf2 deficiency deteriorates diabetic kidney disease in Akita model mice.

ABSTRACT: Oxidative stress is an essential component in the progression of diabetic kidney disease (DKD), and the transcription factor NF-E2-related factor-2 (Nrf2) plays critical roles in protecting the body against oxidative stress. To clarify the roles of Nrf2 in protecting against DKD, in this study we prepared compound mutant mice with diabetes and loss of antioxidative defense. Specifically, we prepared compound Ins2^Akita/+ (Akita) and Nrf2 knockout (Akita::Nrf2^-/-) or Akita and Nrf2 induction (Akita::Keap1^FA/FA) mutant mice. Eighteen-week-old Akita::Nrf2^-/- mice showed more severe diabetic symptoms than Akita mice. In the Akita::Nrf2^-/- mouse kidneys, the glomeruli showed distended capillary loops, suggesting enhanced mesangiolysis. Dista

SUBMITTER: Liu Y 

PROVIDER: S-EPMC9641024 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature