Association between lipid peroxidation biomarkers and microRNA expression profiles.

ABSTRACT:

Background

In-vitro and animal studies demonstrate that epigenetic regulation may play an important role in lipid peroxidation. No human study to date has directly evaluated microRNAs (miRNAs), as epigenetic modulators, in relation to systemic levels of lipid peroxidation.

Objectives

To evaluate associations between systemic levels of lipid peroxidation and miRNA expression profiles in women.

Methods

Included in the analysis were 92 women aged 40-70 years, a subset of the Shanghai Women's Health Study (SWHS). Lipid peroxidation was assessed by urinary markers F₂-isoprostanes (F₂-IsoPs), the products of free radical-catalyzed peroxidation of arachidonic acid, and its major metabolite after β-oxidation, 2,3-dinor-5,6-dihydro-15-F_2t-IsoP

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC9641027 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature