Grim-19 deficiency promotes decidual macrophage autophagy in recurrent spontaneous abortion.

ABSTRACT: Dysregulation of decidual macrophages leads to the occurrence of recurrent spontaneous abortion (RSA). However, the role of macrophages in RSA occurrence remains unclear. In this study, we found that the expression of Grim-19 was decreased, and the expression of autophagy related proteins Beclin1, LC3B II/I and BNIP3 was markedly upregulated in decidual macrophages of RSA patients compared with the normal pregnancy group. Furthermore, we demonstrated that downregulation of GRIM-19 increased the expression of autophagy related proteins Beclin1, LC3B II/I, BNIP3 and the proinflammatory cytokines IL1B, IL6 and TNFa in uterine mononuclear cells of GRIM-19^+/- mice. The proportion of CD45+CD11b+F4/80+LC3B+ cells in GRIM-19^+/- mouse uteri was significantly high

SUBMITTER: Yang Y 

PROVIDER: S-EPMC9641028 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature