Fusion gene recurrence in non-small cell lung cancers and its association with cigarette smoke exposure.

ABSTRACT:

Background

Lung cancer remains the leading cause of cancer-related deaths in the US despite novel treatment protocols, with about 235,000 new cases and 131,000 deaths expected from this cancer in 2021 alone. Lung adenocarcinoma and squamous cell carcinoma, which are both subtypes of non-small cell lung cancer, account for most lung cancer cases, and comparing the molecular signatures in these two cancers can identify novel mechanisms that contribute to non-small cell lung cancer oncogenesis.

Methods

We, in this study, performed a comprehensive gene fusion profiling of these cancers, which is understudied in lung cancers. Using an alignment-free fusion detection tool, 'ChimeRScope', we screened for gene fusions in lung adenocarcinoma and squamous cell carcinoma datasets from

SUBMITTER: Vellichirammal NN 

PROVIDER: S-EPMC9641034 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature