Biomechanical evaluation of a novel repair strategy for intervertebral disc herniation in an ovine lumbar spine model.

ABSTRACT: Following herniation of the intervertebral disc, there is a need for advanced surgical strategies to protect the diseased tissue from further herniation and to minimize further degeneration. Accordingly, a novel tissue engineered implant for annulus fibrosus (AF) repair was fabricated via three-dimensional fiber deposition and evaluated in a large animal model. Specifically, lumbar spine kinetics were assessed for eight (n = 8) cadaveric ovine lumbar spines in three pure moment loading settings (flexion-extension, lateral bending, and axial rotation) and three clinical conditions (intact, with a defect in the AF, and with the defect treated using the AF repair implant). In ex vivo testing, seven of the fifteen evaluated biomechanical measures were significantly altered by the

SUBMITTER: Page MI 

PROVIDER: S-EPMC9641051 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature