Impact of sarcopenia in bladder preservation therapy for muscle-invasive bladder cancer patients: a narrative review.

ABSTRACT:

Background and objective

Muscle-invasive bladder cancer (MIBC) is a biologically aggressive disease and its prognosis is poor. Radical cystectomy (RC) with urinary diversion and lymph node dissection is the gold standard treatment for MIBC patients. Accumulating evidence indicates that sarcopenia, the degenerative and systemic loss of skeletal muscle mass, is a significant predictor of higher rates of mortality and perioperative complications following RC. Recently, bladder preservation therapy has been offered as an alternative in appropriately selected MIBC patients who desire to preserve their bladders and those unfit or unwilling for RC. Here, we performed a narrative review on the impact of sarcopenia on oncological outcomes and complication rates in MIBC patients treated with

SUBMITTER: Fukushima H 

PROVIDER: S-EPMC9641057 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature