Fluorescence in situ hybridization (FISH) to predict the efficacy of Bacillus Calmette-Guerin perfusion in bladder cancer.

ABSTRACT:

Background

Transurethral resection of bladder tumor (TURBT) combined with intravesical Bacillus Calmette-Guérin (BCG) perfusion is a widely accepted treatment for moderate or high risk non-muscular-invasive bladder cancer (BCa). Despite its effectiveness, the recurrence and progression rate of tumor are still high. We evaluated the predictive role of fluorescence in situ hybridization (FISH) for the response to BCG perfusion in BCa.

Methods

Patients with BCa who underwent BCG perfusion and FISH test in our hospital were selected. Logistic regression and Kaplan-Meier methods were used to evaluate the relationship between FISH results and tumor recurrence or progression. COX proportional hazards regression analysis was used to identify risk factors for recurrence or progressio

SUBMITTER: Ke C 

PROVIDER: S-EPMC9641077 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature