Prognostic impact of mitofusin 2 expression in colon cancer.

ABSTRACT:

Background

Mitofusin 2 (MFN2) is involved in several biological processes, including cancer. MFN2 is downregulated in some types of cancer and inhibits cancer cell proliferation, migration, and invasion. However, the relationship between MFN2 and colon cancer remains unknown.

Methods

In this study, MFN2 expression was investigated using The Cancer Genome Atlas (TCGA) and the Human Protein Atlas (HPA), and the associations between prognostic factors and survival outcomes were assessed via univariate and multivariate analyses. Functional enrichment analyses based on Kyoto Encyclopedia of Genes and Genomes (KEGG) resource and Gene Set Enrichment Analysis (GSEA) were carried out.

Results

MFN2 was downregulated in colon cancer tissues compared with paracancerous colon tiss

SUBMITTER: Cheng X 

PROVIDER: S-EPMC9641083 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature