Expression of NMU, PPBP and GNG4 in colon cancer and their influences on prognosis.

ABSTRACT:

Background

This study aims to identify the core genes that influence the prognosis of colon cancer (CC) and analyze their relationships with clinical characteristics.

Methods

The gene expression profiles were downloaded from The Cancer Genome Atlas (TCGA) database. Differentially expressed genes (DEGs) were identified. The top ten core genes were selected by bioinformatics tools and screened through the Oncomine database. The expression of core genes in CC tissues and cells was validated by immunohistochemistry, immunoblotting and quantitative real-time polymerase chain reaction. Spearman correlation was used to analyze the relationship between different parameters. Overall survival was assessed by the Kaplan-Meier method. The area under the curve (AUC) and the receiver oper

SUBMITTER: Chen D 

PROVIDER: S-EPMC9641087 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature