The prognostic role of fatty acid metabolism-related genes in patients with gastric cancer

ABSTRACT:

Background

With the deepening research on fatty acid metabolism, people have achieved a preliminary understanding of it in the development and prognosis of tumors. However, few studies are still on the expression pattern and prognostic value of fatty acid metabolism-related genes in gastric cancer (GC).

Methods

We chose 93 genes relevant to fatty acid metabolism from the Gene Set Enrichment Analysis (GSEA) database. We analyzed differentially expressed genes (DEGs) in The Cancer Genome Atlas (TCGA) patients. Univariate Cox analysis and LASSO regression were used to select the genes most related to prognosis and therefore developed a prognosis model. In addition, a dataset of 76 samples from Gene Expression Omnibus (GEO) selected as a test set to aid in the development of

SUBMITTER: Xu W 

PROVIDER: S-EPMC9641091 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature